Description:

I am interested in mechanisms of oxidative stress induced by ultraviolet light as a putative cause of carcinogenesis. I have characterized endogenous cellular photosensitizers and antioxidants that form a balance in protecting cells from ultraviolet light-mediated toxicity. Nitric oxide is a key mediator of the actions of ultraviolet light. My research has focused on determining if nitric oxide functions as an anti-oxidant or a pro-oxidant. In the BRC I have been characterizing nitric oxide production by a variety of cell types. I have also been investigating the role of peroxynitrite in mediating cellular oxidative stress as measured using a self-referencing oxygen biosensor. Along with Joshua Gray, I have been investigating the role of hyperoxia in mediating cellular nitric oxide production.